What to Expect When Starting Semaglutide or Tirzepatide for Weight Loss

If you’re considering Semaglutide (like Wegovy® or compounded versions) or Tirzepatide (like Mounjaro®) for weight loss—first of all, congratulations on taking a powerful step toward your health goals! These medications are transforming the way we approach sustainable weight loss, especially for people who’ve tried everything and felt stuck.

But let’s talk real-life expectations: what happens when you actually start these medications?

Here’s what to expect—and how to thrive—when starting your journey.

1. Start Slow, Go Steady

Both Semaglutide and Tirzepatide are started at low doses to reduce side effects and allow your body to adjust. Don't expect dramatic weight loss overnight. This is a slow and steady process—but one that’s designed for long-term success, not quick fixes.

2. Side Effects Are Common (but Manageable)

The most common side effects include:

• Nausea

• Constipation or diarrhea

• Fatigue

• Decreased appetite (expected!)

Tips to Manage Side Effects:

• Stay hydrated. Aim for at least 64 oz of water daily—add electrolytes if needed.

• Eat small, high-protein meals. Avoid greasy or heavy foods, especially early on.

• Keep anti-nausea meds on hand. Talk to your provider about Zofran or natural options like ginger chews or peppermint tea.

Pro tip: Don’t force yourself to eat if you’re not hungry—but don’t skip protein entirely, either.

3. Set Realistic Goals

Most people lose 1–2 pounds per week once their dose is optimized. That may not sound like much, but over several months, it adds up in a BIG way. Focus on non-scale victories too:

• Better sleep

• Improved mobility

• More stable energy

• Less inflammation

4. Lifestyle Still Matters

These medications aren’t magic—they work best when combined with healthy habits:

• Protein-rich meals (aim for 80–100g/day)

• Movement you enjoy, even if it’s walking

• Stress management (cortisol can work against your progress)

• Sleep (7–8 hours nightly is ideal)

Think of the medication as a tool that helps quiet cravings and reset your metabolic baseline—your job is to show up consistently and support your body.

5. This Is a Marathon, Not a Sprint

Weight loss is personal. Comparing your journey to others’ will only steal your joy. Your dose, timeline, and results may look completely different—and that’s okay.

Remember, the goal isn’t just weight loss—it’s a healthier, more confident, more energized YOU.